The Pathophysiology of Constipation

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The Pathophysiology of Constipation

Constipation is an extremely common disorder in childhood and is responsible for up to 25% of all pediatric gastroenterological consultations and 3% of all pediatric outpatient visits. In 90% of the cases the disorder is functional in origin and in only 10% is there an underlying organic disorder. Common organic causes of childhood constipation include: congenital defects of the gut; neurologic...

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Functional gastrointestinal (GI) disorders are collections of symptoms attributable to the GI tract in the absence of mucosal, structural, or biochemical disease. Two of the most common disorders, chronic constipation and irritable bowel syndrome (IBS), have common etiopathogenetic features—notably psychosocial disturbances, dysmotility, and heightened sensitivity. In some patients with IBS, th...

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Gastrointestinal (GI) side-effects of chemotherapy are a debilitating and often overlooked clinical hurdle in cancer management. Chemotherapy-induced constipation (CIC) and Diarrhea (CID) present a constant challenge in the efficient and tolerable treatment of cancer and are amongst the primary contributors to dose reductions, delays and cessation of treatment. Although prevalence of CIC is har...

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Constipation in children is a common health problem affecting 0.7% to 29.6% children across the world. Exact etiology for developing symptoms is not clear in children and the majority is considered to have functional constipation. Alteration of rectal and pelvic floor function through the brain-gut axis seems to play a crucial role in the etiology. The diagnosis is often a symptom-based clinica...

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ژورنال

عنوان ژورنال: Annales Nestlé (English ed.)

سال: 2007

ISSN: 1661-4011,0517-8606

DOI: 10.1159/000101714